Anturane and Dilantin Infatabs

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Sulfinpyrazone may increase the blood levels and effects of phenytoin. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with sulfinpyrazone may significantly increase the plasma concentrations and the risk of toxicity of phenytoin. The mechanism for this interaction has not been clearly delineated, but may involve sulfinpyrazone-mediated inhibition of CYP450 2C9, which is the isoenzyme involved in the metabolism of phenytoin. Displacement of phenytoin from its plasma protein binding sites may also contribute to this interaction.

MANAGEMENT: Caution is advised if sulfinpyrazone is used concomitantly with phenytoin. Dosage adjustments as well as clinical and laboratory monitoring should be considered whenever sulfinpyrazone is added to or withdrawn from therapy. Patients should be monitored for the development of phenytoin toxicity such as nausea, vomiting, tremors, ataxia, seizures, drowsiness, lethargy, slurred speech, visual disturbances, and changes in mental status.

Anturane

Generic Name: sulfinpyrazone

Brand name:

Synonyms: n.a.

What is Anturane?

Dilantin Infatabs

Generic Name: phenytoin

Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt

Synonyms: Dilantin

What is Dilantin Infatabs?