Anturane and Starlix

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Coadministration with sulfinpyrazone may increase the plasma concentrations of nateglinide. The mechanism is sulfinpyrazone inhibition of CYP450 2C9, the isoenzyme responsible for the metabolic clearance of nateglinide. In 18 healthy volunteers, pretreatment with sulfinpyrazone (200 mg orally twice daily for 7 days) increased the mean area under the plasma concentration-time curve (AUC) of nateglinide (120 mg single oral dose) by 28% compared to administration of nateglinide alone. Sulfinpyrazone did not affect the mean peak plasma concentration (Cmax), time to reach peak plasma concentration (Tmax), or the elimination half-life of nateglinide. Both treatments were safe and well tolerated. No dosage adjustment of nateglinide should be necessary during coadministration with sulfinpyrazone.

Anturane

Generic Name: sulfinpyrazone

Brand name:

Synonyms: n.a.

What is Anturane?

Starlix

Generic Name: nateglinide

Brand name: Starlix

Synonyms: n.a.

What is Starlix?