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Anzemet Oral and Rifadin IV Intravenous

Determining the interaction of Anzemet Oral and Rifadin IV Intravenous and the possibility of their joint administration.

Check result:
Anzemet Oral <> Rifadin IV Intravenous
Relevance: 15.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Blood levels of hydrodolasetron, the major active metabolite of dolasetron, were decreased 28% when dolasetron was given concomitantly for seven days with rifampin. The mechanism is thought to be induction of the metabolism of hydrodolasetron by rifampin via cytochrome P450 enzymes. The clinician may consider monitoring the patient more closely for decreased dolasetron effect if this combination is used. A similar interaction may occur with rifabutin, however, data are lacking.

References
  • "Product Information. Anzemet (dolasetron)." Hoechst Marion-Roussel Inc, Kansas City, MO.
Anzemet Oral

Generic Name: dolasetron

Brand name: Anzemet

Synonyms: Anzemet

Rifadin IV Intravenous

Generic Name: rifampin

Brand name: Rifadin IV, Rifadin, Rimactane

Synonyms: Rifadin IV (Intravenous), Rifadin IV

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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