Apalutamide and Kaletra Oral Solution

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this interaction is not currently available.CONTRAINDICATED: Coadministration with apalutamide may decrease the plasma concentrations of ritonavir and result in a potential loss of virologic response. The proposed mechanism is increased clearance due to apalutamide-mediated induction of CYP450 3A4, which is the isoenzyme primarily responsible for the metabolism of ritonavir. In addition, concomitant use of ritonavir may increase the plasma levels of apalutamide and risk of adverse effects, including seizures and fracture. The proposed mechanism is ritonavir-mediated inhibition of CYP450 3A4. MANAGEMENT: Given the risk of reduced viral susceptibility and resistance development associated with subtherapeutic antiretroviral drug levels, concomitant use of ritonavir with apalutamide is considered contraindicated. References Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0 Cerner Multum, Inc. "Australian Product Information." O 0 Cerner Multum, Inc. "Canadian Product Information." O 0 (2015): "Product Information. Norvir (ritonavir)." Abbott Pharmaceutical, Abbott Park, IL. View all 4 references

CONTRAINDICATED: Coadministration with apalutamide may decrease the plasma concentrations of ritonavir and result in a potential loss of virologic response. The proposed mechanism is increased clearance due to apalutamide-mediated induction of CYP450 3A4, which is the isoenzyme primarily responsible for the metabolism of ritonavir. In addition, concomitant use of ritonavir may increase the plasma levels of apalutamide and risk of adverse effects, including seizures and fracture. The proposed mechanism is ritonavir-mediated inhibition of CYP450 3A4.

MANAGEMENT: Given the risk of reduced viral susceptibility and resistance development associated with subtherapeutic antiretroviral drug levels, concomitant use of ritonavir with apalutamide is considered contraindicated.

Apalutamide

Generic Name: apalutamide

Brand name: Erleada

Synonyms: n.a.

What is Apalutamide?

Kaletra Oral Solution

Generic Name: lopinavir / ritonavir

Brand name: Kaletra

Synonyms: Kaletra

What is Kaletra Oral Solution?