Apixaban and Dilantin injection
Determining the interaction of Apixaban and Dilantin injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Phenytoin can significantly reduce the blood levels of apixaban, which may make the medication less effective in treating your condition. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Coadministration with potent inducers of both CYP450 3A4 and P-glycoprotein (P-gp) may significantly decrease the plasma concentration of apixaban, which is a substrate of the isoenzyme as well as the efflux transporter. When apixaban was coadministered with the potent CYP450 3A4 and P-gp inducer rifampin (600 mg once a day), mean apixaban peak plasma concentration (Cmax) decreased by 42% and systemic exposure (AUC) decreased by 54%. Increased stroke rates, and paradoxically, increased major bleeding have been reported in patients with atrial fibrillation taking concomitant inducers with either apixaban or warfarin.
MANAGEMENT: Concomitant use of apixaban with dual potent inducers of both CYP450 3A4 and P-gp should generally be avoided, since efficacy of apixaban may be compromised.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- "Product Information. Eliquis (apixaban)." Bristol-Myers Squibb Canada Inc, Montreal, IN.
Generic Name: apixaban
Brand name: Eliquis, Eliquis Starter Pack for Treatment of DVT and PE
Synonyms: n.a.
Generic Name: phenytoin
Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt
Synonyms: Dilantin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Apixaban-Dilantin Kapseals
- Apixaban-Dilantin-125
- Apixaban-Dilantin-30
- Apixaban-Dilatrate-SR
- Apixaban-Dilaudid
- Apixaban-Dilaudid (Hydromorphone Injection)
- Dilantin injection-Aplenzin
- Dilantin injection-Aplicare One Hydrogen Peroxide
- Dilantin injection-Aplicare One Tincture Of Iodine Topical
- Dilantin injection-Aplisol
- Dilantin injection-Apo-Amoxi
- Dilantin injection-Apo-Amoxi Clav