Aplenzin and Effient

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Coadministration with prasugrel may alter the metabolism of drugs that are substrates of CYP450 2B6. Prasugrel is a weak inhibitor of the isoenzyme. In healthy subjects, prasugrel decreased systemic exposure to hydroxybupropion, a CYP450 2B6-mediated metabolite of bupropion, by 23%. This change is not considered clinically significant. Therefore, prasugrel is not anticipated to have a significant effect on the pharmacokinetics of drugs that are primarily metabolized by CYP450 2B6 such as cyclophosphamide, efavirenz, halothane, nevirapine, propofol, selegiline, and tamoxifen.

Aplenzin

Generic Name: bupropion

Brand name: Aplenzin, Budeprion XL, Forfivo XL, Wellbutrin XL, Buproban, Wellbutrin SR, Zyban, Zyban Advantage Pack

Synonyms: n.a.

What is Aplenzin?

Effient

Generic Name: prasugrel

Brand name: Effient

Synonyms: n.a.

What is Effient?