Apo-Cyclosporine Oral and Prestalia

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using amLODIPine together with cycloSPORINE can increase the blood levels and effects of both medications. Contact your doctor if your condition changes or you experience increased side effects. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration of amlodipine with cyclosporine may increase the plasma concentrations and the risk of adverse effects of both drugs. The proposed mechanism by which amlodipine increases cyclosporine exposure has not been clearly delineated, but may involve inhibition of CYP450 3A4 and/or P-glycoprotein; cyclosporine may increase amlodipine exposure by inhibiting its metabolism via the CYP450 3A4 enzymatic pathway. Studies have revealed that coadministration of amlodipine with cyclosporine in renal transplant patients resulted in variable increases in trough concentrations of cyclosporine (average 0% to 40%).

MANAGEMENT: Although the interaction has not been studied, caution is advised if amlodipine and cyclosporine are used in combination, particularly in renal transplant patients. Cyclosporine blood levels and renal function should be monitored more closely whenever amlodipine is added to or withdrawn from therapy, and the cyclosporine dosage adjusted as necessary. Similarly, dosage adjustments as well as clinical and laboratory monitoring of amlodipine should be considered whenever cyclosporine is added to or withdrawn from therapy. During concomitant treatment, patients should be advised to notify their physician if they experience signs and symptoms of cyclosporine toxicity such as nausea, vomiting, diarrhea, abdominal pain, dizziness, fatigue, headache, tremors, and convulsions or adverse effects associated with amlodipine such as hypotension or edema. In addition, concurrent use may also increase the risk of gingival overgrowth.

Apo-Cyclosporine Oral

Generic Name: cyclosporine

Brand name: Gengraf, Neoral, Sandimmune, Sandimmune

Synonyms: Cyclosporine (oral/injection), CycloSPORINE (Systemic)

What is Apo-Cyclosporine Oral?

Prestalia

Generic Name: amlodipine / perindopril

Brand name: Prestalia

Synonyms: n.a.

What is Prestalia?