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Apo-Sulfatrim and Selexipag

Determining the interaction of Apo-Sulfatrim and Selexipag and the possibility of their joint administration.

Check result:

Apo-Sulfatrim <> Selexipag

Relevance: 26.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Trimethoprim may increase the blood levels of selexipag. This may increase side effects such as diarrhea, nausea, vomiting, flushing, anemia, and decreased appetite. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration with inhibitors of CYP450 2C8 may increase the plasma concentrations of selexipag and its active metabolite. The interaction has not been studied; however, both selexipag and the metabolite undergo oxidative metabolism by CYP450 2C8 and 3A4.

MANAGEMENT: Caution is advised when selexipag is prescribed with CYP450 2C8 inhibitors. Dosage adjustments as well as clinical and laboratory monitoring of selexipag should be considered whenever a CYP450 2C8 inhibitor is added to or withdrawn from therapy. Patients should be monitored for potentially increased side effects such as diarrhea, nausea, vomiting, flushing, anemia, and decreased appetite.

References

"Product Information. Uptravi (selexipag)." Actelion Pharmaceuticals US Inc, South San Francisco, CA.

Apo-Sulfatrim

Generic Name: sulfamethoxazole / trimethoprim

Brand name: Bactrim, Bactrim DS, Bactrim IV, Septra IV, SMZ-TMP DS, Sulfatrim Pediatric, Septra, Sulfatrim, Bethaprim, Cotrim, Uroplus, Uroplus DS, Cotrim DS, Bactrim Pediatric, Bethaprim Pediatric, Sulfatrim Suspension, Cotrim Pediatric, Septra DS

Synonyms: Sulfamethoxazole and trimethoprim, Sulfamethoxazole and Trimethoprim

What is Apo-Sulfatrim?

Selexipag

Generic Name: selexipag

Brand name: Uptravi, Uptravi Titration Pack

Synonyms: n.a.

What is Selexipag?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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