Apokyn and Fosnetupitant and Palonosetron

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using palonosetron and apomorphine is not recommended. Taking these drugs together can cause symptoms of feeling light-headed, loss of consciousness, chest pain or heavy feeling, or tremors. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

CONTRAINDICATED: Severe hypotension and loss of consciousness has been reported during the concomitant use of apomorphine and ondansetron. The mechanism is unknown. Other 5-HT3 antagonists may also interact. In addition, dolasetron, palonosetron, and apomorphine have been associated with varying degrees of QT interval prolongation, which may increase the risk of torsades de pointes in susceptible patients.

MANAGEMENT: The concomitant use of apomorphine and 5-HT3 antagonists is contraindicated by the manufacturer.

Apokyn

Generic Name: apomorphine

Brand name: Apokyn, APO-Go, APO-Go Pen, Uprima

Synonyms: n.a.

What is Apokyn?

Fosnetupitant and Palonosetron

Generic Name: fosnetupitant / palonosetron

Brand name: Akynzeo for injection

Synonyms: Fosnetupitant and palonosetron (injection)

What is Fosnetupitant and Palonosetron?