Apokyn and Tigan Intramuscular

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using trimethobenzamide together with apomorphine can increase the blood levels or add to the side effects of either medication. This may be more likely to occur in older adults or those with a debilitating condition. Talk with your doctor before using these medications together. Call the doctor if you have side effects such as drowsiness, dizziness, lightheadedness, and confusion. You should avoid activities requiring mental alertness until you know how these medications affect you. If you experience increased episodes of falling asleep during normal daily activities, you should avoid driving and other potentially hazardous activities. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Central nervous system effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects, especially in elderly or debilitated patients. Both trimethobenzamide and apomorphine have sedative properties. Patients may suddenly fall asleep during activities of daily living while on apomorphine therapy. In clinical trials (n=522), trimethobenzamide was used for up to 33 months for the prevention and treatment of apomorphine-induced nausea and vomiting and appeared to be tolerated well. The manufacturer recommends starting trimethobenzamide (300 mg orally three times a day) before the first dose of apomorphine is given.

MANAGEMENT: Monitoring for potentially excessive or prolonged CNS depression is recommended. Patients should be made aware of the possibility of additive CNS effects (e.g., drowsiness, dizziness, lightheadedness, confusion) and counseled to avoid activities requiring mental alertness until they know how these agents affect them. If patients experience increased episodes of falling asleep during normal daily activities, they should avoid driving and other potentially hazardous activities until they have contacted their physician.

Apokyn

Generic Name: apomorphine

Brand name: Apokyn, APO-Go, APO-Go Pen, Uprima

Synonyms: n.a.

What is Apokyn?

Tigan Intramuscular

Generic Name: trimethobenzamide

Brand name: Benzacot, Ticon, Tigan

Synonyms: Tigan (oral/injection), Tigan

What is Tigan Intramuscular?