Apomorphine and Netupitant and Palonosetron Hydrochloride
Determining the interaction of Apomorphine and Netupitant and Palonosetron Hydrochloride and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using palonosetron and apomorphine is not recommended. Taking these drugs together can cause symptoms of feeling light-headed, loss of consciousness, chest pain or heavy feeling, or tremors. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:CONTRAINDICATED: Severe hypotension and loss of consciousness has been reported during the concomitant use of apomorphine and ondansetron. The mechanism is unknown. Other 5-HT3 antagonists may also interact. In addition, dolasetron, palonosetron, and apomorphine have been associated with varying degrees of QT interval prolongation, which may increase the risk of torsades de pointes in susceptible patients.
MANAGEMENT: The concomitant use of apomorphine and 5-HT3 antagonists is contraindicated by the manufacturer.
- "Product Information. Aloxi (palonosetron)." MGI Pharma Inc, Minnetonka, MN.
- "Product Information. Anzemet (dolasetron)." Hoechst Marion-Roussel Inc, Kansas City, MO.
- "Product Information. Apokyn (apomorphine)." Mylan Pharmaceuticals Inc, Morgantown, WV.
Generic Name: apomorphine
Brand name: Apokyn, APO-Go, APO-Go Pen, Uprima
Synonyms: n.a.
Generic Name: netupitant / palonosetron
Brand name: Akynzeo
Synonyms: Netupitant and palonosetron, Netupitant and Palonosetron
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Apomorphine-Neuac
- Apomorphine-Neuac Gel
- Apomorphine-Neuac Kit
- Apomorphine-Neulasta
- Apomorphine-Neulasta Delivery Kit
- Apomorphine-Neulasta Onpro Kit
- Netupitant and Palonosetron Hydrochloride-Apomorphine Ampules
- Netupitant and Palonosetron Hydrochloride-Apomorphine Cartridges and Pens
- Netupitant and Palonosetron Hydrochloride-Apomorphine Hydrochloride
- Netupitant and Palonosetron Hydrochloride-Apomorphine Subcutaneous
- Netupitant and Palonosetron Hydrochloride-Apra
- Netupitant and Palonosetron Hydrochloride-Apraclonidine