Apomorphine Hydrochloride and Doxercalciferol

• Generic Name: apomorphine
• Dosage Forms: n.a.
• Other Brand Names: Apokyn, APO-Go, APO-Go Pen, Uprima

Acute, intermittent treatment of episodes of hypomobility (i.e., “off” episodes, including end-of-dose “wearing off” and unpredictable “on-off” episodes) associated with advanced Parkinson’s disease (designated an orphan drug by FDA for this use).

Used as an adjunct to other antiparkinsonian agents (e.g., levodopa, oral dopamine receptor agonists).

Formerly used to induce vomiting in the early management of acute oral drug overdose and in certain cases of oral poisoning (dose: 5–6 mg sub-Q).

• Generic Name: doxercalciferol
• Dosage Forms: n.a.
• Other Brand Names: Hectorol

Treatment of secondary hyperparathyroidism in patients with chronic kidney disease (CKD) undergoing dialysis.

Oral doxercalciferol also used in the treatment of secondary hyperparathyroidism in patients with stage 3 or 4 CKD who do not yet require maintenance dialysis (predialysis patients).

Suppresses elevated serum or plasma parathyroid hormone (PTH) concentrations associated with secondary hyperparathyroidism in patients with CKD. Deficient production of biologically active vitamin D metabolites leads to secondary hyperparathyroidism, which contributes to the development of metabolic bone disease.