Apomorphine Hydrochloride and Gadavist

• Generic Name: apomorphine
• Dosage Forms: n.a.
• Other Brand Names: Apokyn, APO-Go, APO-Go Pen, Uprima

Acute, intermittent treatment of episodes of hypomobility (i.e., “off” episodes, including end-of-dose “wearing off” and unpredictable “on-off” episodes) associated with advanced Parkinson’s disease (designated an orphan drug by FDA for this use).

Used as an adjunct to other antiparkinsonian agents (e.g., levodopa, oral dopamine receptor agonists).

Formerly used to induce vomiting in the early management of acute oral drug overdose and in certain cases of oral poisoning (dose: 5–6 mg sub-Q).

• Generic Name: gadobutrol
• Dosage Forms: injection
• Other Brand Names: Gadavist

Gadavist (gadobutrol) is a contrast agent that has magnetic properties. It is used in combination with magnetic resonance imaging (MRI) or magnetic resonance angiography (MRA) to allow blood vessels, organs, and other non-bony tissues to be seen more clearly.

Gadavist is used to help diagnose certain disorders of the brain and spine (central nervous system), or the blood vessels of the kidneys, and the heart. Gadavist is also used with MRI of the breast to help detect breast cancer.