Aprepitant and Dilantin Infatabs

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using phenytoin together with aprepitant may decrease the effects of either medication. Contact your doctor if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Theoretically, coadministration of phenytoin and aprepitant may result in decreased plasma concentrations of both drugs. The mechanism is phenytoin induction of CYP450 3A4, of which aprepitant is a substrate, and aprepitant induction of CYP450 2C9, of which phenytoin is a substrate.

MANAGEMENT: During coadministration of aprepitant and phenytoin, the possibility of a diminished therapeutic response to both drugs should be considered. Pharmacologic response should be monitored more closely whenever one or the other drug is added to or withdrawn from therapy, and the dosage(s) adjusted as necessary.

Aprepitant

Generic Name: aprepitant

Brand name: Cinvanti, Emend, Emend 3-Day, Emend 2-Day

Synonyms: n.a.

What is Aprepitant?

Dilantin Infatabs

Generic Name: phenytoin

Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt

Synonyms: Dilantin

What is Dilantin Infatabs?