Aprepitant and Zovia 1/35

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using ethinyl estradiol together with aprepitant can alter the effects of ethinyl estradiol. Aprepitant can make birth control pills less effective, which may result in pregnancy. Before taking aprepitant, tell your doctor if you use birth control pills. You may also experience breakthrough bleeding. Alternative or additional methods of birth control should be considered during aprepitant therapy. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADDITIONAL CONTRACEPTION RECOMMENDED: Aprepitant and its prodrug, fosaprepitant, may reduce the efficacy of low-dose hormonal contraceptives during and for up to 28 days after treatment. The proposed mechanism is aprepitant induction of CYP450 3A4, the isoenzyme partially responsible for the metabolic clearance of contraceptive hormones. According to the product labeling, coadministration of aprepitant (100 mg once a day for 14 days) and an oral contraceptive containing ethinyl estradiol-norethindrone (35 mcg-1 mg) resulted in a 43% decrease in the area under the plasma concentration-time curve (AUC) of ethinyl estradiol and an 8% decrease in the AUC of norethindrone. In another study, coadministration of an oral contraceptive containing ethinyl estradiol-norethindrone on days 1 through 21 and aprepitant on days 8 through 10 (125 mg on day 8 and 80 mg/day on days 9 and 10, with ondansetron 32 mg IV on day 8 and oral dexamethasone 12 mg on day 8 and 8 mg/day on days 9, 10, and 11) resulted in a 19% decrease in the ethinyl estradiol AUC on day 10 and up to a 64% decrease in ethinyl estradiol trough concentrations during days 9 through 21. While there was no effect of aprepitant on the AUC of norethindrone on day 10, up to a 60% decrease in norethindrone trough concentrations was observed during days 9 through 21.

MANAGEMENT: Women using low-dose hormonal contraceptives should be advised of the risk of breakthrough bleeding and unintended pregnancy during concomitant therapy with aprepitant or fosaprepitant. Alternative or additional methods of birth control is recommended during treatment with aprepitant and for one month following the last dose of aprepitant. Data are not available for single-dosing of aprepitant 40 mg. However, since the timing of aprepitant administration relative to ovulation could cause contraceptive failure, the same precaution as for the 125 mg/80 mg regimen should be observed. Intrauterine systems are unlikely to be significantly affected because of their local action. Input from a gynecologist or similar expert on adequate contraception, including emergency contraception, should be sought as needed.

Aprepitant

Generic Name: aprepitant

Brand name: Cinvanti, Emend, Emend 3-Day, Emend 2-Day

Synonyms: n.a.

What is Aprepitant?

Zovia 1/35

Generic Name: ethinyl estradiol / ethynodiol

Brand name: Kelnor, Zovia 1/35, Zovia 1/50, Demulen 1/35, Demulen 1/50, Zovia 1/35e, Kelnor 1/50, Kelnor 1/35, Zovia 1/50e

Synonyms: Zovia 1/35E

What is Zovia 1/35?