Aprepitant Capsules and Dronedarone Hydrochloride

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using dronedarone together with aprepitant may increase the blood levels of both medications. Contact your doctor if your condition changes or you experience increased side effects. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. High blood levels of dronedarone can cause an irregular heart rhythm that may be serious and potentially life-threatening. You may be more susceptible if you have a heart condition called congenital long QT syndrome, other cardiac diseases, conduction abnormalities, or electrolyte disturbances (for example, magnesium or potassium loss due to severe or prolonged diarrhea or vomiting). Your doctor may want you to have ECGs performed regularly while you are on dronedarone. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations during treatment. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration of dronedarone with a drug that is both a substrate as well as inhibitor of CYP450 3A4 may result in increased plasma concentrations of both drugs. Dronedarone itself is also a substrate and moderate inhibitor of CYP450 3A4. Theoretically, competitive and/or noncompetitive metabolic inhibition may occur. Because dronedarone is associated with concentration-dependent prolongation of the QT interval, increased levels may potentiate the risk of ventricular arrhythmias such as torsade de pointes and sudden death.

MANAGEMENT: Caution is advised if dronedarone is prescribed in combination with a drug that is an inhibitor of CYP450 3A4. Pharmacologic response to dronedarone should be monitored more closely whenever a CYP450 3A4 inhibitor is added to or withdrawn from therapy. Patients should be advised to seek medical attention if they experience symptoms that could indicate dronedarone toxicity such as excessive fatigue, fainting, difficulty breathing, chest pain or tightness, bradycardia, or symptoms of torsade de pointes such as dizziness, palpitations, irregular heartbeat, shortness of breath, and syncope. Likewise, clinical and/or laboratory monitoring may be appropriate for the coadministered drug following the addition or withdrawal of dronedarone, and the dosage adjusted as necessary.

Aprepitant Capsules

Generic Name: aprepitant

Brand name: Cinvanti, Emend, Emend 3-Day, Emend 2-Day

Synonyms: Aprepitant

What is Aprepitant Capsules?

Dronedarone Hydrochloride

Generic Name: dronedarone

Brand name: Multaq

Synonyms: Dronedarone

What is Dronedarone Hydrochloride?