Apresoline Injection and Orphenadrine, aspirin, and caffeine
Determining the interaction of Apresoline Injection and Orphenadrine, aspirin, and caffeine and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Before taking hydrALAZINE, tell your doctor if you also use aspirin. This combination may cause dizziness, headaches, or blurred vision. If you take both medications together, tell your doctor if you have any of these symptoms. You may need a dose adjustment or need your blood pressure checked more often. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Nonsteroidal anti-inflammatory drugs (NSAIDs) may attenuate the antihypertensive effect of hydralazine and dihydralazine. This interaction suggests that prostaglandins play a pivotal role in the vasodilatory effects of hydralazine. However, data have been conflicting.
MANAGEMENT: Recommended management consists of monitoring the antihypertensive effectiveness of hydralazine or dihydralazine during therapy, increasing the dosage as necessary, or decreasing or substituting another drug for the NSAID.
- Cinquegrani MP, Liang CS "Indomethacin attenuates the hypotensive action of hydralazine." Clin Pharmacol Ther 39 (1986): 564-70
Generic Name: hydralazine
Brand name: Apresoline
Synonyms: Apresoline
Generic Name: aspirin / caffeine / orphenadrine
Brand name: Norgesic Forte, Orphengesic Forte, Norgesic, Orphengesic
Synonyms: Aspirin, caffeine, and orphenadrine, Orphenadrine Aspirin Caffeine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Apresoline Injection-Orphenate
- Apresoline Injection-Orphengesic
- Apresoline Injection-Orphengesic Forte
- Apresoline Injection-Orsythia
- Apresoline Injection-Ortho D
- Apresoline Injection-Ortho Evra
- Orphenadrine, aspirin, and caffeine-Apri
- Orphenadrine, aspirin, and caffeine-Apriso
- Orphenadrine, aspirin, and caffeine-Aprizio Pak
- Orphenadrine, aspirin, and caffeine-Aprodine
- Orphenadrine, aspirin, and caffeine-Aprotinin
- Orphenadrine, aspirin, and caffeine-Aptensio XR