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Aptiom and Phenytoin Sodium

Determining the interaction of Aptiom and Phenytoin Sodium and the possibility of their joint administration.

Check result:

Aptiom <> Phenytoin Sodium

Relevance: 25.09.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using eslicarbazepine together with phenytoin may affect the blood levels and effects of both medications. Specifically, eslicarbazepine levels may decrease and phenytoin levels may increase. Contact your doctor if your condition worsens or you experience excessive effects of phenytoin such as nausea, vomiting, twitching eye movements, blurred vision, slurred speech, loss of balance or coordination, tremors, sluggishness, confusion, or hallucinations. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSE: Coadministration of eslicarbazepine acetate and phenytoin may decrease the systemic exposure to the active metabolite, eslicarbazepine, and increase the exposure to phenytoin. The proposed mechanisms are induction of glucuronidation by phenytoin and inhibition of CYP450 2C19 metabolism by eslicarbazepine. In healthy study subjects administered eslicarbazepine acetate 1200 mg once daily with phenytoin, eslicarbazepine systemic exposure (AUC) decreased by an average of 31% to 33% and phenytoin AUC increased by 31% to 35%.

MANAGEMENT: Close observation for clinical and laboratory evidence of altered effects is recommended during concomitant use of eslicarbazepine acetate and phenytoin, particularly when one drug is started or discontinued. Patients should be advised to contact their physician if they experience loss of seizure control or signs and symptoms of phenytoin toxicity such as nausea, vomiting, tremors, ataxia, lethargy, slurred speech, visual disturbances, or changes in mental status. A dosage increase for eslicarbazepine acetate and/or dosage reduction for phenytoin may be required based on efficacy and tolerability.

References

"Product Information. Aptiom (eslicarbazepine)." Sunovion Pharmaceuticals Inc, Marlborough, MA.
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Bialer M, Soares-da-Silva P "Pharmacokinetics and drug interactions of eslicarbazepine acetate." Epilepsia 53 (2012): 935-46

Aptiom

Generic Name: eslicarbazepine

Brand name: Aptiom

Synonyms: n.a.

What is Aptiom?

Phenytoin Sodium

Generic Name: phenytoin

Brand name: Dilantin, Dilantin Infatabs, Phenytek, Phenytoin Sodium, Prompt

Synonyms: n.a.

What is Phenytoin Sodium?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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