Aptiom and Simvastatin orally disintegrating tablet
Determining the interaction of Aptiom and Simvastatin orally disintegrating tablet and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Eslicarbazepine may reduce the blood levels and effects of simvastatin. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with eslicarbazepine acetate may decrease the plasma concentrations of simvastatin. The proposed mechanism is eslicarbazepine induction of the CYP450 3A4-mediated metabolism of simvastatin. In healthy study subjects, simvastatin systemic exposure (AUC) decreased by an average of 50% when coadministered with eslicarbazepine acetate 800 mg once daily.
MANAGEMENT: The potential for diminished therapeutic effects of simvastatin should be considered when prescribed in combination with eslicarbazepine acetate. A dosage increase for simvastatin may be required based on efficacy and tolerability.
- "Product Information. Aptiom (eslicarbazepine)." Sunovion Pharmaceuticals Inc, Marlborough, MA.
- EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports. Available from: URL: http://www.ema.europa.eu/ema/index.jsp?curl=pages/includes/medicines/medicines_landingpage.jsp&mid."
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Generic Name: simvastatin
Brand name: Zocor, Flolipid
Synonyms: Simvastatin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Aptiom-Simvastatin Tablets
- Aptiom-Sinarest
- Aptiom-Sinarest Nasal
- Aptiom-Sinarest Sinus
- Aptiom-Sine-Off Maximum Strength
- Aptiom-Sinelee
- Simvastatin orally disintegrating tablet-Aptivus
- Simvastatin orally disintegrating tablet-Aptivus (Tipranavir Capsules)
- Simvastatin orally disintegrating tablet-Aptivus (Tipranavir Oral Solution)
- Simvastatin orally disintegrating tablet-Aqua Gem-E
- Simvastatin orally disintegrating tablet-Aqua-Ban
- Simvastatin orally disintegrating tablet-Aqua-E