Aptivus and Biaxin (Clarithromycin Oral Suspension)

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using clarithromycin together with tipranavir may increase the effects of both medications. Contact your doctor if you experience increased side effects or if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSE: Coadministration of clarithromycin with tipranavir and low-dose ritonavir may result in increased plasma concentrations of both clarithromycin and tipranavir. The proposed mechanism is competitive inhibition of CYP450 3A4, the isoenzyme responsible for the metabolic clearance of all three drugs. In 24 study subjects, clarithromycin (500 mg twice a day for 12 days) increased the mean peak plasma concentration (Cmax), area under the concentration-time curve (AUC) and trough plasma concentration (Cmin) of steady-state tipranavir (500 mg with ritonavir 200 mg twice a day for 7 days) by 40%, 66%, and 100%, respectively, compared to historical data. Clarithromycin AUC and Cmin increased by 19% and 68%, respectively, while Cmax, AUC and Cmin of 14-hydroxyclarithromycin decreased by more than 90% each.

MANAGEMENT: No dosage adjustment of tipranavir or clarithromycin is necessary for patients with normal renal function. For patients with creatinine clearance between 30 and 60 mL/min, the dosage of clarithromycin should be reduced by 50%. For patients with creatinine clearance below 30 mL/min, the dosage of clarithromycin should be reduced by 75%.

Aptivus

Generic Name: tipranavir

Brand name: Aptivus

Synonyms: n.a.

What is Aptivus?

Biaxin (Clarithromycin Oral Suspension)

Generic Name: clarithromycin

Brand name: Biaxin, Biaxin XL

Synonyms: Biaxin (Oral Suspension), Biaxin

What is Biaxin (Clarithromycin Oral Suspension)?