Aptivus and Divalproex

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using tipranavir together with divalproex sodium may decrease the effects of divalproex sodium. Contact your doctor if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with tipranavir/ritonavir may decrease the plasma concentrations of drugs that are substrates of UGT1A1. The mechanism is accelerated clearance due to induction of UGT1A1 activity by tipranavir.

MANAGEMENT: Caution is advised if tipranavir/ritonavir must be used concomitantly with medications that undergo metabolism by UGT1A1, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever tipranavir/ritonavir is added to or withdrawn from therapy.

Aptivus

Generic Name: tipranavir

Brand name: Aptivus

Synonyms: n.a.

What is Aptivus?

Divalproex

Generic Name: divalproex sodium

Brand name: Depakote ER, Depakote Sprinkles, Depakote, Depakene, Depacon

Synonyms: Divalproex sodium

What is Divalproex?