Aptivus and Up and Up Anti-Diarrheal Solution

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using loperamide together with tipranavir may alter the effects of loperamide. Contact your doctor if your condition changes. You may need a dose adjustment or special tests if use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with tipranavir in combination with low-dose ritonavir may decrease the plasma concentrations of loperamide. The mechanism probably involves reduced absorption and increased first-pass clearance of loperamide due to induction of the intestinal P-glycoprotein drug efflux pump by tipranavir. In 24 study subjects, tipranavir/ritonavir (750 mg/200 mg twice a day for 10 days) decreased the mean peak plasma concentration (Cmax) and area under the plasma concentration-time curve (AUC) of loperamide (16 mg single dose) by 61% and 51%, respectively, compared to administration of loperamide without tipranavir/ritonavir. Tipranavir/ritonavir also reduced the Cmax and AUC of the metabolite N-demethyl-loperamide by 79% and 77%, respectively. Tipranavir trough plasma concentration (Cmin) was reduced 26%.

MANAGEMENT: Clinicians and patients should be aware that pharmacologic effects of loperamide may be reduced during coadministration with tipranavir/ritonavir.

Aptivus

Generic Name: tipranavir

Brand name: Aptivus

Synonyms: n.a.

What is Aptivus?

Up and Up Anti-Diarrheal Solution

Generic Name: loperamide

Brand name: Diamode, Imodium A-D, Imodium A-D EZ Chews, Imodium A-D New Formula, Imodium, Maalox Anti-Diarrheal, Pepto Diarrhea Control, Imotil, Kao-Paverin, Kaopectate 1-D, Diar-Aid, Anti-Diarrheal [OTC]

Synonyms: n.a.

What is Up and Up Anti-Diarrheal Solution?