Aptivus (Tipranavir Capsules) and Intelence

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Ask your doctor before using tipranavir together with etravirine, this may decrease the effects of etravirine. Contact your doctor if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration with tipranavir/ritonavir may significantly decrease the plasma concentrations of etravirine. The mechanism of interaction has not been described but may involve tipranavir induction of CYP450 3A4 and ritonavir induction of CYP450 2C19 and 2C9, as etravirine is a substrate of these isoenzymes. In 19 study subjects administered etravirine with tipranavir/ritonavir (500 mg/200 mg) twice a day, etravirine peak plasma concentration (Cmax), systemic exposure (AUC) and trough plasma concentration (Cmin) decreased by 71%, 76% and 82%, respectively. Tipranavir Cmax, AUC and Cmin increased by 14%, 18% and 24%, respectively.

MANAGEMENT: Given the risk of reduced viral susceptibility and resistance development associated with subtherapeutic antiretroviral drug levels, the use of etravirine in combination with tipranavir/ritonavir should be avoided.

Aptivus (Tipranavir Capsules)

Generic Name: tipranavir

Brand name: Aptivus

Synonyms: Aptivus

What is Aptivus (Tipranavir Capsules)?

Intelence

Generic Name: etravirine

Brand name: Intelence

Synonyms: n.a.

What is Intelence?