Aptivus (Tipranavir Oral Solution) and Tacrolimus Intravenous
Determining the interaction of Aptivus (Tipranavir Oral Solution) and Tacrolimus Intravenous and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using tacrolimus together with tipranavir may alter the effects of tacrolimus. Contact your doctor if your condition changes. You may need a dose adjustment or special tests if use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with tipranavir in combination with ritonavir may alter the pharmacokinetics of immunosuppressants that are dual substrates of CYP450 3A4 and P-glycoprotein. The potential changes cannot be predicted due to the conflicting effects of tipranavir and ritonavir on CYP450 3A4 and P-glycoprotein. Specifically, ritonavir is a potent inhibitor of CYP450 3A4 and tend to reduce clearance of substrate drugs, while tipranavir is a potent inducer of P-glycoprotein intestinal efflux transporters and tend to increase clearance of substrate drugs.
MANAGEMENT: Caution is advised if immunosuppressants such as cyclosporine, sirolimus, and tacrolimus are coadministered with tipranavir/ritonavir. More frequent concentration monitoring of these drugs is recommended until blood levels have been stabilized.
- "Product Information. Aptivus (tipranavir)." Boehringer-Ingelheim, Ridgefield, CT.
Generic Name: tipranavir
Brand name: Aptivus
Synonyms: Aptivus
Generic Name: tacrolimus
Brand name: Astagraf XL, Envarsus XR, Prograf, Hecoria
Synonyms: Tacrolimus (oral and injection), Tacrolimus (Systemic)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Aptivus (Tipranavir Oral Solution)-Tacrolimus oral and injection
- Aptivus (Tipranavir Oral Solution)-Tacrolimus Oral, Intravenous
- Aptivus (Tipranavir Oral Solution)-Tactinal
- Aptivus (Tipranavir Oral Solution)-Tadalafil
- Aptivus (Tipranavir Oral Solution)-Tadalafil Tablets (Cialis)
- Aptivus (Tipranavir Oral Solution)-Tadalafil Tablets (Pulmonary Hypertension)
- Tacrolimus Intravenous-Aqua Gem-E
- Tacrolimus Intravenous-Aqua-Ban
- Tacrolimus Intravenous-Aqua-E
- Tacrolimus Intravenous-AquADEKs
- Tacrolimus Intravenous-Aquamephyton
- Tacrolimus Intravenous-Aquanil HC