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Aquazide H and Colestid (Colestipol Tablets)

Determining the interaction of Aquazide H and Colestid (Colestipol Tablets) and the possibility of their joint administration.

Check result:

Aquazide H <> Colestid (Colestipol Tablets)

Relevance: 02.05.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Colestipol may interfere with the absorption of hydroCHLOROthiazide when these medications are taken at the same time. This may reduce the blood levels and effects of hydroCHLOROthiazide. To prevent or minimize the interaction, hydroCHLOROthiazide should be taken at least 1 hour before or 4 hours after the colestipol dose. Contact your doctor if your condition changes or your symptoms worsen during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSING INTERVAL: Colestipol may decrease the gastrointestinal absorption of thiazide diuretics by binding them in the gut. The interaction has been studied with hydrochlorothiazide (HCTZ) and chlorothiazide. In six healthy volunteers, administration of a single 10 gm dose of colestipol two minutes before a 75 mg oral dose of HCTZ reduced the total urinary excretion of HCTZ by 43%. Similar effects were also observed for plasma HCTZ levels. In another study, a single 4 gm dose of colestipol given simultaneously or one hour after a 1 gm dose of chlorothiazide reduced the 24-hour urinary excretion of chlorothiazide by 58% and 54%, respectively, in ten subjects.

MANAGEMENT: Thiazide diuretics should be administered as far apart from colestipol as possible, but at least 1 hour before or 4 hours after colestipol. Patients should be monitored for potentially diminished therapeutic effects, and the thiazide dosage adjusted if necessary.

References

Kauffman RE, Azarnoff DL "Effect of colestipol on gastrointestinal absorption of chlorothiazide in man." Clin Pharmacol Ther 14 (1973): 886-90
Hunninghake DB, King S, LaCroix K "The effect of cholestyramine and colestipol on the absorption of hydrochlorothiazide." Int J Clin Pharmacol Ther Toxicol 20 (1982): 151-4
"Product Information. Colestid (colestipol HCI)." Pharmacia and Upjohn, Kalamazoo, MI.

Aquazide H

Generic Name: hydrochlorothiazide

Brand name: Aquazide H, HydroDIURIL, Microzide,

Synonyms: Aquazide H (Oral)

What is Aquazide H?

Colestid (Colestipol Tablets)

Generic Name: colestipol

Brand name: Colestid, Colestid Flavored

Synonyms: Colestid

What is Colestid (Colestipol Tablets)?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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