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Aquazide H and Coumadin Injection

Determining the interaction of Aquazide H and Coumadin Injection and the possibility of their joint administration.

Check result:

Aquazide H <> Coumadin Injection

Relevance: 02.05.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Thiazide diuretics may reduce intravascular volume. Higher plasma levels of clotting factors and decreased anticoagulant effect may result; however the effects may not be clinically significant. Management consists of monitoring coagulation parameters during the initial phase of coadministration. Patients should be advised to promptly report any signs of blood clots (e.g. chest pain, shortness of breath, sudden loss of vision, or pain, redness or swelling in an extremity).

References

Ku LL, Ward CO, Durgin SJ "A clinical study of drug interaction and anticoagulant therapy." Drug Intell Clin Pharm 4 (1970): 300-6
Robinson DS, Sylwester D "Interaction of commonly prescribed drugs and warfarin." Ann Intern Med 72 (1970): 853-6
Koch-Weser J, Sellers EM "Drug interactions with coumarin anticoagulants (first of two parts)." N Engl J Med 285 (1971): 487-98

Aquazide H

Generic Name: hydrochlorothiazide

Brand name: Aquazide H, HydroDIURIL, Microzide,

Synonyms: Aquazide H (Oral)

What is Aquazide H?

Coumadin Injection

Generic Name: warfarin

Brand name: Coumadin, Jantoven

Synonyms: Coumadin

What is Coumadin Injection?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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