Aquazide H and Dofetilide

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using hydroCHLOROthiazide and dofetilide is not recommended. Taking these drugs together can affect the rhythm of your heart. Call your doctor if you have symptoms of irregular heartbeat, chest tightness, blurred vision or nausea. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

CONTRAINDICATED: Coadministration with hydrochlorothiazide (HCTZ) may increase the plasma concentrations and pharmacodynamic effects of dofetilide. The mechanism of interaction has not been described. Concurrent administration of HCTZ (50 mg once a day) and dofetilide (500 mcg twice a day) for 5 days (following 2 days of diuretic use at half dose) has been shown to increase dofetilide peak plasma concentration (Cmax) by 21% and systemic exposure (AUC) by 27%. However, the QTc increase over time and the maximum QTc increase values went up by 197% and 95%, respectively. In patients who received HCTZ-triamterene (50 mg-100 mg once a day) with dofetilide for 5 days, dofetilide Cmax was increased by 16% and AUC by 30%, while the QTc increase over time and maximum QTc increase values went up by 190% and 84%, respectively. The increased QT prolongation effects can be explained by a combination of the increase in dofetilide exposure and the HCTZ-induced reductions in serum potassium.

MANAGEMENT: Because QT interval prolongation may be associated with serious ventricular arrhythmias such as torsade de pointes tachycardia, use of dofetilide in combination with hydrochlorothiazide is considered contraindicated.

Aquazide H

Generic Name: hydrochlorothiazide

Brand name: Aquazide H, HydroDIURIL, Microzide,

Synonyms: Aquazide H (Oral)

What is Aquazide H?

Dofetilide

Generic Name: dofetilide

Brand name: Tikosyn

Synonyms: n.a.

What is Dofetilide?