Aquazide H and Topiramate

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this interaction is not currently available.MONITOR: Coadministration with thiazide-like diuretics, such as hydrochlorothiazide, may enhance the hypokalemic effects and increase the serum concentrations of topiramate. The mechanism for this interaction has not been delineated. The results of a clinical study involving healthy subjects showed that following administration of hydrochlorothiazide, the Cmax and AUC of topiramate increased by 27% and 29%, respectively. In addition, decreases in serum potassium were greater when hydrochlorothiazide and topiramate were given concomitantly compared to when either was given alone. MANAGEMENT: Until more information is available, caution is advised if topiramate is administered with a thiazide-like diuretic, such as hydrochlorothiazide. Dosage adjustments as well as clinical and laboratory monitoring of topiramate should be considered whenever a thiazide-like diuretic is added to or withdrawn from therapy. Serum potassium levels should also be monitored during concomitant therapy. Patients should be observed for the development of topiramate adverse effects. References "Product Information. Topamax (topiramate)." Ortho Pharmaceutical Corporation, Raritan, NJ. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0 Cerner Multum, Inc. "Australian Product Information." O 0 "Product Information. Topiramate (topiramate)." Cipla USA Inc., Miami, FL. View all 4 references

MONITOR: Coadministration with thiazide-like diuretics, such as hydrochlorothiazide, may enhance the hypokalemic effects and increase the serum concentrations of topiramate. The mechanism for this interaction has not been delineated. The results of a clinical study involving healthy subjects showed that following administration of hydrochlorothiazide, the Cmax and AUC of topiramate increased by 27% and 29%, respectively. In addition, decreases in serum potassium were greater when hydrochlorothiazide and topiramate were given concomitantly compared to when either was given alone.

MANAGEMENT: Until more information is available, caution is advised if topiramate is administered with a thiazide-like diuretic, such as hydrochlorothiazide. Dosage adjustments as well as clinical and laboratory monitoring of topiramate should be considered whenever a thiazide-like diuretic is added to or withdrawn from therapy. Serum potassium levels should also be monitored during concomitant therapy. Patients should be observed for the development of topiramate adverse effects.

Aquazide H

Generic Name: hydrochlorothiazide

Brand name: Aquazide H, HydroDIURIL, Microzide,

Synonyms: Aquazide H (Oral)

What is Aquazide H?

Topiramate

Generic Name: topiramate

Brand name: Qudexy XR Sprinkle, Topamax, Topamax Sprinkle, Trokendi XR, Topiragen, Qudexy XR

Synonyms: n.a.

What is Topiramate?