Aqueous Vitamin E and Cholestyramine Light
Determining the interaction of Aqueous Vitamin E and Cholestyramine Light and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using cholestyramine together with vitamin E may decrease the effects of vitamin E. Vitamin E should be administered at least 4 hours before cholestyramine. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:ADJUST DOSING INTERVAL: Bile acid sequestrants and the phosphate binder, sevelamer, can decrease the absorption of fat-soluble vitamins A, D, E, and K. In non-clinical safety studies, rats administered colesevelam at doses greater than 30-fold the projected human clinical dose developed hemorrhage in association with vitamin K deficiency. In a crossover study involving healthy subjects, coadministration of sevelamer with calcitriol resulted in a significant reduction in bioavailability for calcitriol (calcitriol with sevelamer vs calcitriol alone: AUC 137 pg*h/mL vs 318 pg*h/mL and Cmax 40.1 pg/mL vs 49.7 pg/mL, respectively).
MANAGEMENT: Oral vitamin supplements should be administered at least 4 hours before colesevelam and either 1 hour before or 4 to 6 hours after other bile acid sequestrants and sevelamer.
- Peirce D, Hossack S, Poole L, et.al "The effect of sevelamer carbonate and lanthanum carbonate on the pharmacokinetics of oral calcitriol." Nephrol Dial Transplant 26 (2011): 1615-21
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- "Product Information. Rocaltrol (calcitriol)." Roche Laboratories, Nutley, NJ.
- Cerner Multum, Inc. "Australian Product Information." O 0
- "Product Information. Welchol (colesevelam)" Daiichi Sankyo, Inc., Parsippany, NJ.
Generic Name: vitamin e
Brand name: Aqua-E, Aquasol E, Aquavite-E, Aqueous Vitamin E, E-400 Clear, Alph-E, Alph-E-Mixed, Alph-E-Mixed 1000, E-400, E-400-Clear, E-400-Mixed, E-Max-1000, E-Pherol, Formula E 400, Natural Vitamin E, Nutr-E-Sol, Vita-Plus E
Synonyms: Vitamin E, Vitamin E (Systemic)
Generic Name: cholestyramine
Brand name: Cholestyramine Light, Prevalite, Questran, Questran Light, Locholest, Locholest Light, Questran Light Packets, Prevalite Packets, Questran Packets
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Aqueous Vitamin E-Cholestyramine Resin
- Aqueous Vitamin E-Choletec
- Aqueous Vitamin E-Cholic acid
- Aqueous Vitamin E-Choline magnesium trisalicylate
- Aqueous Vitamin E-Choline Magnesium Trisalicylate Liquid
- Aqueous Vitamin E-Cholografin Meglumine
- Cholestyramine Light-Arakoda
- Cholestyramine Light-Aralen
- Cholestyramine Light-Aralen Phosphate
- Cholestyramine Light-Aranelle
- Cholestyramine Light-Aranesp
- Cholestyramine Light-Aranesp (Darbepoetin Alfa Prefilled Syringes)