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Aralen Phosphate and Inderal

Determining the interaction of Aralen Phosphate and Inderal and the possibility of their joint administration.

Check result:

Aralen Phosphate <> Inderal

Relevance: 11.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

In vitro and animal studies have suggested that chloroquine may increase serum levels of some oral beta-blockers. The possible mechanism is inhibition of CYP450 2D6 hepatic metabolism. It is recommended that the patient be monitored for beta-blocker toxicity during coadministration and for beta-blocker efficacy when chloroquine is discontinued. Renally excreted beta-blockers such as atenolol, carteolol, nadolol, or sotalol are not expected to interact.

References

Somer M, Kallio J, Pesonen U, Pyykko K, Huupponen R, Scheinin M "Influence of hydroxychloroquine on the bioavailability of oral metoprolol." Br J Clin Pharmacol 49 (2000): 549-54
Lancaster DL, Adio RA, Tai KK, Simooya OO, Broadhead GD, Tucker GT, Lennard MS "Inhibition of metoprolol metabolism by chloroquine and other antimalarial drugs." J Pharm Pharmacol 42 (1990): 267-71
Seffart G ed. "Drug Dosage in Renal Insufficiency." Dordrecht, South Holland, : Kluwer Academic Publishers (1991):
"Product Information. Corgard (nadolol)." Bristol-Myers Squibb, Princeton, NJ.
"Product Information. Betapace (sotalol)." Berlex, Richmond, CA.
"Product Information. Tenormin (atenolol)." ICN Pharmaceuticals Inc, Cost Mesa, CA.

Aralen Phosphate

Generic Name: chloroquine

Brand name: Aralen Phosphate, Aralen Hydrochloride

Synonyms: n.a.

What is Aralen Phosphate?

Inderal

Generic Name: propranolol

Brand name: Inderal LA, Inderal XL, InnoPran XL, Inderal, Hemangeol, InnoPran XL

Synonyms: n.a.

What is Inderal?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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