Aralen Phosphate and Methenamine, Phenyl Salicylate, Methylene Blue, Benzoic Acid, Hyoscyamine

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Coadministration with methylene blue may modestly decrease the concentrations of chloroquine in whole blood. In 24 healthy volunteers, methylene blue (130 mg orally twice daily for 3 days) decreased the area under the whole blood concentration-time curve (AUC normalized to body weight) of chloroquine (1000 mg orally (males) and 750 mg orally (females) for 2 days, then half the dose on the third day) by 21% and that of the pharmacologically active metabolite desethylchloroquine by 35% compared to placebo. The renal clearance and terminal elimination half-life of chloroquine and the metabolic ratio between chloroquine and desethylchloroquine exposure were not significantly altered. No serious adverse events occurred in the study. This interaction is unlikely to have major relevance on the clinical outcome of chloroquine treatment.

Aralen Phosphate

Generic Name: chloroquine

Brand name: Aralen Phosphate, Aralen Hydrochloride

Synonyms: n.a.

What is Aralen Phosphate?

Methenamine, Phenyl Salicylate, Methylene Blue, Benzoic Acid, Hyoscyamine

Generic Name: benzoic acid / hyoscyamine / methenamine / methylene blue / phenyl salicylate

Brand name: Hyophen, Prosed/DS, Urophen MB

Synonyms: n.a.

What is Methenamine, Phenyl Salicylate, Methylene Blue, Benzoic Acid, Hyoscyamine?