Arformoterol Tartrate and Triprolidine Hydrochloride

• Generic Name: arformoterol
• Dosage Forms: n.a.
• Other Brand Names: Brovana

Long-term treatment of bronchoconstriction associated with COPD, including chronic bronchitis and emphysema.

Long-acting β2-adrenergic agonists recommended as maintenance therapy in patients with moderate (e.g., forced expiratory volume in 1 second [FEV1] ≥50 but <80% of predicted) to very severe COPD (e.g., FEV1 <30% of predicted or <50% of predicted plus chronic respiratory failure) who have persistent symptoms not relieved by as-needed therapy with short-acting bronchodilators (e.g., ipratropium, β2-adrenergic agonist).

Regular treatment with long-acting bronchodilators more effective and convenient than treatment with short-acting bronchodilators. Superiority of one long-acting bronchodilator over another currently not established. If inadequate response, may use a combination of long-acting bronchodilators, such as a long-acting inhaled anticholinergic agent (tiotropium) and a long-acting β2-adrenergic agonist.

In patients with severe (e.g., FEV1 <50% of predicted, history of repeated exacerbations) to very severe COPD, add regular treatment with an inhaled corticosteroid to long-acting bronchodilator therapy. If inadequate response or limiting adverse effects occur, add or substitute extended-release oral theophylline.

Not to be used for immediate relief of acute exacerbations of COPD. Use short-acting inhaled β2-agonist intermittently (as needed) for acute symptoms of COPD. (See Acute Exacerbations of COPD under Cautions.) Efficacy and safety of long-acting bronchodilators, with or without inhaled corticosteroids, during acute exacerbations of COPD not established.

• Generic Name: triprolidine
• Dosage Forms: n.a.
• Other Brand Names: Histex, M-Hist PD, Vanaclear PD, Vanahist PD, Zymine, Zymine XR, Tripohist, Histex Syrup, Histex PD Drops, Histex PDX

Symptomatic relief of seasonal (e.g., hay fever) or perennial (nonseasonal) allergic rhinitis or nonallergic (vasomotor) rhinitis.

Used in fixed combination with other agents (e.g., pseudoephedrine) for symptomatic relief of rhinorrhea, sneezing, oronasopharyngeal itching, lacrimation, itching eyes, and/or other symptoms (e.g., sinus congestion) associated with seasonal or perennial allergic rhinitis or nonallergic rhinitis.

Symptomatic relief of allergic conjunctivitis caused by foods or inhaled allergens.

Symptomatic treatment of mild, uncomplicated allergic skin manifestations of urticaria and angioedema.

Used in fixed combination with other agents (e.g., pseudoephedrine) for self-medication for symptomatic relief of sinus congestion and other symptoms associated with the common cold.