Argatroban and Naprosyn Oral Suspension
Determining the interaction of Argatroban and Naprosyn Oral Suspension and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Ask your doctor before using naproxen together with argatroban. Using naproxen with argatroban can cause you to bleed more easily. You may need a dose adjustment in addition to testing of your prothrombin time or International Normalized Ratio (INR). Call your doctor promptly if you have any unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Theoretically, the coadministration of nonsteroidal anti-inflammatory drugs (NSAIDs) and thrombin inhibitors may potentiate the risk of bleeding. NSAIDs interfere with platelet adhesion and aggregation and may prolong bleeding time in healthy individuals. While these effects are generally slight and of relatively short duration for most NSAIDs (except aspirin) at recommended dosages, they may be of pronounced clinical significance when combined with the effects of thrombin inhibitors on the clotting cascade. NSAIDs are also known to cause dose-related gastrointestinal bleeding, which may be complicated by anticoagulant therapy. However, little clinical data exist regarding an actual interaction.
MANAGEMENT: Until further data are available, products containing NSAIDs, especially if given chronically or in high dosages, should preferably be avoided in patients receiving thrombin inhibitors. Close clinical and laboratory observation for bleeding complications is recommended if concurrent therapy is necessary.
- "Product Information. Acova (argatroban)" SmithKline Beecham, Philadelphia, PA.
- "Product Information. Angiomax (bivalirudin)" The Medicines Compny, Cambridge, MA.
- "Product Information. Refludan (lepirudin)." Hoechst Marion-Roussel Inc, Kansas City, MO.
Generic Name: naproxen
Brand name: Aleve, EC-Naprosyn, Flanax Pain Reliever, Midol Extended Relief, Naprelan 375, Naprosyn, Anaprox-DS, Naprelan 500, Flanax, Naprelan, Anaprox, Naproxen Sodium, Aleve Caplet, Aleve Gelcap, Aleve Easy Open Arthritis
Synonyms: Naprosyn
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Argatroban-Naprosyn Tablets
- Argatroban-Naproxen
- Argatroban-Naproxen and Diphenhydramine
- Argatroban-Naproxen and Esomeprazole
- Argatroban-Naproxen and pseudoephedrine
- Argatroban-Naproxen CR Tablets
- Naprosyn Oral Suspension-Argatroban Intravenous
- Naprosyn Oral Suspension-Arginine
- Naprosyn Oral Suspension-Arginine Intravenous
- Naprosyn Oral Suspension-Aricept
- Naprosyn Oral Suspension-Aricept (Donepezil 23 mg Tablets)
- Naprosyn Oral Suspension-Aricept (Donepezil Tablets)