Argatroban Intravenous and Sudafed 12 Hour Pressure + Pain
Determining the interaction of Argatroban Intravenous and Sudafed 12 Hour Pressure + Pain and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Ask your doctor before using naproxen together with argatroban. Using naproxen with argatroban can cause you to bleed more easily. You may need a dose adjustment in addition to testing of your prothrombin time or International Normalized Ratio (INR). Call your doctor promptly if you have any unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Theoretically, the coadministration of nonsteroidal anti-inflammatory drugs (NSAIDs) and thrombin inhibitors may potentiate the risk of bleeding. NSAIDs interfere with platelet adhesion and aggregation and may prolong bleeding time in healthy individuals. While these effects are generally slight and of relatively short duration for most NSAIDs (except aspirin) at recommended dosages, they may be of pronounced clinical significance when combined with the effects of thrombin inhibitors on the clotting cascade. NSAIDs are also known to cause dose-related gastrointestinal bleeding, which may be complicated by anticoagulant therapy. However, little clinical data exist regarding an actual interaction.
MANAGEMENT: Until further data are available, products containing NSAIDs, especially if given chronically or in high dosages, should preferably be avoided in patients receiving thrombin inhibitors. Close clinical and laboratory observation for bleeding complications is recommended if concurrent therapy is necessary.
- "Product Information. Acova (argatroban)" SmithKline Beecham, Philadelphia, PA.
- "Product Information. Angiomax (bivalirudin)" The Medicines Compny, Cambridge, MA.
- "Product Information. Refludan (lepirudin)." Hoechst Marion-Roussel Inc, Kansas City, MO.
Generic Name: argatroban
Brand name: Acova
Synonyms: Argatroban (Intravenous)
Generic Name: naproxen / pseudoephedrine
Brand name: Aleve-D Sinus & Cold, Aleve-D Sinus & Headache, Sudafed 12 Hour Pressure + Pain, Aleve Cold and Sinus, Aleve Sinus & Headache, Sudafed PSE, Aleve-D Cold and Sinus, Sudafed Sinus & Pain 12 Hour, Sinus & Cold-D, Sudafed Sinus 12 Hour Pressure + Pain
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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- Argatroban Intravenous-Sudafed PE Cold & Cough Child
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