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Aricept Oral Solution and Seconal Sodium

Determining the interaction of Aricept Oral Solution and Seconal Sodium and the possibility of their joint administration.

Check result:
Aricept Oral Solution <> Seconal Sodium
Relevance: 16.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Secobarbital may reduce the blood levels and effects of donepezil. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration with drugs that are inducers of the CYP450 3A4 and/or 2D6 enzymatic pathways may decrease the plasma concentrations of donepezil. The mechanism is accelerated clearance of donepezil due to enhanced CYP450 activities.

MANAGEMENT: While clinical data are lacking, the possibility of a diminished therapeutic response to donepezil should be considered in patients receiving concomitant inducer agents.

References
  • "Product Information. Aricept (donepezil)." Pfizer US Pharmaceuticals, New York, NY.
Aricept Oral Solution

Generic Name: donepezil

Brand name: Aricept, Aricept ODT

Synonyms: Aricept

Seconal Sodium

Generic Name: secobarbital

Brand name: Seconal Sodium, Seconal

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle