Arimidex and Nolvadex

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Ask your doctor before using tamoxifen together with anastrozole. Using these medications together can make anastrozole less effective. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration with tamoxifen may decrease the plasma concentrations of anastrozole. The mechanism of interaction has not been described. In one clinical trial, coadministration of tamoxifen (20 mg/day) and anastrozole (1 mg/day) in breast cancer patients resulted in decreased anastrozole plasma concentration by 27% compared to administration of anastrozole alone. In addition, at a median follow-up of 33 months, the combination did not demonstrate any efficacy benefit over tamoxifen therapy alone in all patients as well as in the hormone receptor-positive subpopulation, and this treatment arm was discontinued from the trial. The pharmacokinetics of tamoxifen and its pharmacologically active N-desmethyl metabolite were not affected.

MANAGEMENT: Concomitant use of tamoxifen and anastrozole should be avoided.

Arimidex

Generic Name: anastrozole

Brand name: Arimidex

Synonyms: n.a.

What is Arimidex?

Nolvadex

Generic Name: tamoxifen

Brand name: Nolvadex, Soltamox

Synonyms: n.a.

What is Nolvadex?