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Armodafinil and Delavirdine

Determining the interaction of Armodafinil and Delavirdine and the possibility of their joint administration.

Check result:

Armodafinil <> Delavirdine

Relevance: 23.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using delavirdine together with armodafinil may decrease the effects of delavirdine. Contact your doctor if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration with modafinil (the racemate) or armodafinil (the R-enantiomer) may decrease the plasma concentrations of delavirdine due to induction of CYP450 3A4 metabolism. Conversely, delavirdine may increase the plasma concentrations of modafinil due to inhibition of CYP450 3A4. The clinical significance is unknown. Modafinil and armodafinil are modest CYP450 3A4 inducers in vitro, while delavirdine is considered a potent inhibitor of the isoenzyme.

MANAGEMENT: Given the risk of reduced viral susceptibility and resistance development associated with decreased or subtherapeutic antiretroviral drug levels, caution is advised if modafinil or armodafinil must be used in patients treated with delavirdine. Clinical monitoring for altered effects of both drugs may be appropriate following addition or withdrawal of one or the other drug.

References

Robertson P, Decory HH, Madan A, Parkinson A "In vitro inhibition and induction of human hepatic cytochrome P450 enzymes by modafinil." Drug Metab Dispos 28 (2000): 664-71
"Product Information. Rescriptor (delavirdine)." Pharmacia and Upjohn, Kalamazoo, MI.
"Product Information. Provigil (modafinil)." Cephalon, Inc, West Chester, PA.
"Product Information. Nuvigil (armodafinil)." Cephalon Inc, West Chester, PA.

Armodafinil

Generic Name: armodafinil

Brand name: Nuvigil

Synonyms: n.a.

What is Armodafinil?

Delavirdine

Generic Name: delavirdine

Brand name: Rescriptor

Synonyms: n.a.

What is Delavirdine?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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