Artemether and lumefantrine and Rifadin IV
Determining the interaction of Artemether and lumefantrine and Rifadin IV and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using artemether together with rifAMPin is not recommended. Combining these medications may significantly reduce the blood levels of artemether, which may make the medication less effective in treating malaria. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:CONTRAINDICATED: Coadministration with potent inducers of CYP450 3A4 may significantly decrease the plasma concentrations of artemether and lumefantrine, both of which are primarily metabolized by the isoenzyme. Loss of antimalarial efficacy may occur. In six HIV-1 and tuberculosis coinfected adults without malaria, administration of artemether-lumefantrine (six-dose regimen over 3 days) with the potent CYP450 3A4 inducer rifampin (600 mg orally daily) decreased the systemic exposure (AUC) to artemether, dihydroartemisinin (the active metabolite of artemether) and lumefantrine by 89%, 85% and 68%, respectively.
MANAGEMENT: Concomitant use of artemether-lumefantrine with potent CYP450 3A4 inducers is considered contraindicated.
- "Product Information. Coartem (artemether-lumefantrine)." Novartis Pharmaceuticals, East Hanover, NJ.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Cerner Multum, Inc. "Australian Product Information." O 0
Generic Name: artemether / lumefantrine
Brand name: Coartem
Synonyms: Artemether and Lumefantrine
Generic Name: rifampin
Brand name: Rifadin IV, Rifadin, Rimactane
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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