Articaine Hydrochloride and Tolterodine Tartrate

• Generic Name: articaine / epinephrine
• Dosage Forms: n.a.
• Other Brand Names: Septocaine, Articadent, Orabloc, Septocaine with Epinephrine 1: 100, 000, Septocaine with Epinephrine 1: 200, Zorcaine

Local, infiltrative, or regional (i.e., nerve block) anesthesia in simple and complex dental and periodontal procedures.

Anesthetic activity comparable to that of lidocaine, mepivacaine, and prilocaine.

• Generic Name: tolterodine
• Dosage Forms: n.a.
• Other Brand Names: Detrol, Detrol LA

Treatment of overactive bladder for the relief of symptoms associated with voiding such as urge urinary incontinence, urgency, and frequency. Efficacy not established in pediatric patients.

Tolterodine (conventional tablets) appears to be as effective as conventional oxybutynin in reducing urinary symptoms in patients with overactive bladder and is associated with a lower incidence of dry mouth.

Tolterodine (2 mg twice daily as conventional tablets) appears to be less effective than extended-release oxybutynin (10 mg once daily as extended-release tablets) in reducing urinary symptoms in patients with overactive bladder. The incidence of adverse effects (e.g., dry mouth) is similar between conventional tolterodine tartrate and extended-release oxybutynin.

Single daily doses of extended-release capsules of tolterodine tartrate appear to be slightly more effective in relieving certain urinary symptoms (i.e., urge incontinence) than 2 daily doses of conventional tablets of the drug.