Asparaginase and Ethinyl Estradiol, Drospirenone, and Levomefolate
Determining the interaction of Asparaginase and Ethinyl Estradiol, Drospirenone, and Levomefolate and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this interaction is not currently available.GENERALLY AVOID: Theoretically, there is potential for an indirect interaction between asparaginase and oral contraceptives. The mechanism may involve asparaginase's hepatotoxicity, which may impair oral contraceptives' hepatic clearance. MANAGEMENT: The use of oral contraceptives during asparaginase treatment is not recommended. Other non-oral contraceptive methods should be used in women of childbearing potential. According to the manufacturer, females of reproductive potential should be advised to use effective contraception during asparaginase treatment and for at least 3 to 6 months after the last dose. References Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0 Cerner Multum, Inc. "Australian Product Information." O 0 "Product Information. Asparlas (calaspargase pegol)." Servier, Boston, MA.
Professional:GENERALLY AVOID: Theoretically, there is potential for an indirect interaction between asparaginase and oral contraceptives. The mechanism may involve asparaginase's hepatotoxicity, which may impair oral contraceptives' hepatic clearance.
MANAGEMENT: The use of oral contraceptives during asparaginase treatment is not recommended. Other non-oral contraceptive methods should be used in women of childbearing potential. According to the manufacturer, females of reproductive potential should be advised to use effective contraception during asparaginase treatment and for at least 3 to 6 months after the last dose.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Cerner Multum, Inc. "Australian Product Information." O 0
- "Product Information. Asparlas (calaspargase pegol)." Servier, Boston, MA.
Generic Name: asparaginase escherichia coli
Brand name:
Synonyms: Asparaginase (E. coli)
Generic Name: drospirenone / ethinyl estradiol / levomefolate calcium
Brand name: Beyaz, Safyral, Rajani, Tydemy
Synonyms: Drospirenone, ethinyl estradiol, and levomefolate
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Asparaginase-Ethinyl estradiol, folic acid, and levonorgestrel
- Asparaginase-Ethinyl Estradiol, Norethindrone, and Ferrous Fumarate
- Asparaginase-Ethiodized oil Injection
- Asparaginase-Ethiodol
- Asparaginase-Ethionamide
- Asparaginase-Ethmozine
- Ethinyl Estradiol, Drospirenone, and Levomefolate-Asparaginase (E. coli)
- Ethinyl Estradiol, Drospirenone, and Levomefolate-Asparaginase (Erwinia)
- Ethinyl Estradiol, Drospirenone, and Levomefolate-Asparaginase Erwinia chrysanthemi
- Ethinyl Estradiol, Drospirenone, and Levomefolate-Asparaginase erwinia chrysanthemi Intramuscular
- Ethinyl Estradiol, Drospirenone, and Levomefolate-Asparlas
- Ethinyl Estradiol, Drospirenone, and Levomefolate-Aspercreme Lidocaine