Asparaginase Erwinia chrysanthemi and Methotrexate Sodium
Determining the interaction of Asparaginase Erwinia chrysanthemi and Methotrexate Sodium and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Asparaginase Erwinia chrysanthemi may reduce the effects of methotrexate in the treatment of some conditions. The interaction may occur even if you are receiving methotrexate after you have stopped treatment with asparaginase Erwinia chrysanthemi, as there may be residual low levels of the drug in your system. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Nonclinical data suggest that the concomitant use of L-asparaginase and methotrexate may reduce the antineoplastic effect of methotrexate. The mechanism and clinical significance are unknown.
MANAGEMENT: It is recommended to avoid concomitant or sequential use while plasma asparagine levels are below normal.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Cerner Multum, Inc. "Australian Product Information." O 0
Generic Name: asparaginase erwinia chrysanthemi
Brand name: Erwinaze
Synonyms: Asparaginase (Erwinia)
Generic Name: methotrexate
Brand name: Otrexup, Rasuvo, Rheumatrex Dose Pack, Trexall, Xatmep, Methotrexate Sodium, Preservative Free
Synonyms: Methotrexate
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Asparaginase Erwinia chrysanthemi-Methotrexate Tablets
- Asparaginase Erwinia chrysanthemi-Methoxsalen
- Asparaginase Erwinia chrysanthemi-Methoxsalen (Systemic)
- Asparaginase Erwinia chrysanthemi-Methoxsalen (Topical)
- Asparaginase Erwinia chrysanthemi-Methoxsalen Extracorporeal Solution
- Asparaginase Erwinia chrysanthemi-Methoxsalen Hard-Gelatin Capsules
- Methotrexate Sodium-Asparaginase erwinia chrysanthemi Intramuscular
- Methotrexate Sodium-Asparlas
- Methotrexate Sodium-Aspercreme Lidocaine
- Methotrexate Sodium-Aspergum
- Methotrexate Sodium-Aspir 81
- Methotrexate Sodium-Aspir-Low