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Aspirin and Bumetanide Injection

Determining the interaction of Aspirin and Bumetanide Injection and the possibility of their joint administration.

Check result:

Aspirin <> Bumetanide Injection

Relevance: 09.04.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Salicylates in anti-inflammatory dosages may blunt the diuretic and natriuretic response to loop diuretics. The interaction has been demonstrated in patients with ascites secondary to liver cirrhosis and in normal volunteers. Investigators theorize that salicylates may inhibit the renal effects of loop diuretics that are mediated by prostaglandins, including increases in sodium excretion, renal blood flow, and plasma renin activity. Since renal prostaglandins are believed to play a major role in the maintenance of renal blood flow and glomerular filtration rate in cirrhotics with ascites, the interaction may be particularly important in this population. No clinical interventions are generally required, but the possibility of a potential interaction should be considered in patients with ascites treated with a loop diuretic and salicylate or salicylate-related product.

References

Tobert MB, Ostaszewski T, Reger B, Meisinger MA, Cook TJ "Diflunisal-furosemide interaction." Clin Pharmacol Ther 27 (1980): 289-90
Valette H, Apoil E "Interaction between salicylate and two loop diuretics." Br J Clin Pharmacol 8 (1979): 592-4
Bartoli E, Arras S, Faedda R, Soggia G, Satta A, Olmeo NA "Blunting of furosemide diuresis by aspirin in man." J Clin Pharmacol 20 (1980): 452-8
Wilson TW, McCauley FA, Wells HD "Effects of low-dose aspirin on responsses to furosemide." J Clin Pharmacol 26 (1986): 100-5
Kaufman J, Hamburger R, Matheson J, Flamenbaum W "Bumetanide-induced diuresis and natriuresis: effect of prostaglandin synthetase inhibition." J Clin Pharmacol 21 (1981): 663-7
Planas R, Arroyo V, Rimola A, Perez-Ayuso RM, Rodes J "Acetylsalicylic acid suppresses the renal hemodynamic effect and reduces the diuretic action of furosemide in cirrhosis with ascites." Gastroenterology 84 (1983): 247-52
Salerno F, Lorenzano E, Maggi A, Badalamenti S, Minuz P, Degan M, Chinea B, Scotti A "Effects of imidazole-salicylate on renal function and the diuretic action of furosemide in cirrhotic patients with ascites." J Hepatol 19 (1993): 279-84

Aspirin

Generic Name: aspirin

Brand name: Arthritis Pain, Aspir 81, Aspir-Low, Bayer Childrens Aspirin, Durlaza, Ecotrin, Ecpirin, Fasprin, Halfprin, Miniprin, Aspiritab, Bayer, Bayer Low Strength, Bayer Children's, St. Joseph 81 mg Adult

Synonyms: n.a.

What is Aspirin?

Bumetanide Injection

Generic Name: bumetanide

Brand name: Bumex

Synonyms: Bumetanide (oral/injection), Bumetanide

What is Bumetanide Injection?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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