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Aspirin and Dilantin Infatabs

Determining the interaction of Aspirin and Dilantin Infatabs and the possibility of their joint administration.

Check result:

Aspirin <> Dilantin Infatabs

Relevance: 09.04.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

In vitro studies suggest that salicylates may displace phenytoin from plasma protein-binding sites. The potential for phenytoin toxicity exists. The clinical significance is unknown. One case of phenytoin toxicity has been reported in a patient taking aspirin. However, clinical studies in healthy subjects and epileptic patients (taking phenytoin and 1500 mg aspirin/day) have not reported significant pharmacokinetic changes, adverse effects, or loss of seizure control.

References

Neuvonen PJ, Lehtovaara R, Bardy A, Elomaa E "Antipyretic analgesics in patients on antiepileptic drug therapy." Eur J Clin Pharmacol 15 (1979): 263-8
Fraser DG, Ludden TM, Evens RP, Sutherland EW "Displacement of phenytoin from plasma binding sites by salicylate." Clin Pharmacol Ther 27 (1980): 165-9
Leonard RF, Knott PJ, Rankin GO, et al "Phenytoin-salicylate interaction." Clin Pharmacol Ther 29 (1981): 56-60
Paxton JW "Effects of aspirin on salivary and serum phenytoin kinetics in healthy subjects." Clin Pharmacol Ther 27 (1980): 170-8
Lunde PK, Rane A, Yaffe SJ, Lund L, Sjoqvist F "Plasma protein binding of diphenylhydantoin in man: interaction with other drugs and the effect of temperature and plasma dilution." Clin Pharmacol Ther 11 (1970): 846-55

Aspirin

Generic Name: aspirin

Brand name: Arthritis Pain, Aspir 81, Aspir-Low, Bayer Childrens Aspirin, Durlaza, Ecotrin, Ecpirin, Fasprin, Halfprin, Miniprin, Aspiritab, Bayer, Bayer Low Strength, Bayer Children's, St. Joseph 81 mg Adult

Synonyms: n.a.

What is Aspirin?

Dilantin Infatabs

Generic Name: phenytoin

Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt

Synonyms: Dilantin

What is Dilantin Infatabs?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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