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Aspirin and Effient

Determining the interaction of Aspirin and Effient and the possibility of their joint administration.

Check result:
Aspirin <> Effient
Relevance: 09.04.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using prasugrel together with aspirin may increase the risk of bleeding, especially gastrointestinal bleeding. Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. You should seek immediate medical attention if you experience potential signs and symptoms of gastrointestinal injury such as abdominal pain, bloating, dizziness, lightheadedness, loss of appetite, nausea, vomiting (especially with fresh or dried blood that looks like coffee grounds), and red or black, tarry stools. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Concomitant use of prasugrel with other agents that affect hemostasis including aspirin may increase the risk of bleeding. According to the product labeling, the effects of prasugrel on platelet aggregation were not significantly affected by aspirin 150 mg daily. However, bleeding time was increased compared with either drug alone. The safety of prasugrel during coadministration with other salicylates has not been established, but potentiation of gastrointestinal bleeding should be considered.

MANAGEMENT: Although prasugrel may be used with aspirin, caution is advised during coadministration with any salicylate, especially in patients at risk for gastrointestinal ulceration or bleeding. Close clinical and laboratory observation for hemorrhagic complications is recommended. Patients should be advised to contact their physician if they develop potential signs and symptoms of gastrointestinal injury such as abdominal pain, bloating, dizziness, lightheadedness, hematemesis, anorexia, and/or black, tarry stools.

References
  • "Product Information. Effient (prasugrel)." Lilly, Eli and Company, Indianapolis, IN.
Aspirin

Generic Name: aspirin

Brand name: Arthritis Pain, Aspir 81, Aspir-Low, Bayer Childrens Aspirin, Durlaza, Ecotrin, Ecpirin, Fasprin, Halfprin, Miniprin, Aspiritab, Bayer, Bayer Low Strength, Bayer Children's, St. Joseph 81 mg Adult

Synonyms: n.a.

Effient

Generic Name: prasugrel

Brand name: Effient

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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