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Aspirin and Feverfew

Determining the interaction of Aspirin and Feverfew and the possibility of their joint administration.

Check result:

Aspirin <> Feverfew

Relevance: 09.04.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Theoretically, feverfew extracts may potentiate the effects of anticoagulants, platelet inhibitors, and thrombolytic agents, possibly increasing the risk of bleeding. In vitro studies have shown feverfew to interfere with hemostasis and platelet aggregation by neutralizing platelet sulfhydryl groups as well as preventing prostaglandin synthesis. However, bleeding complications and interactions with hematologic agents have not been reported. Moreover, pharmacologic effects may be highly variable due to inconsistencies in formulation and potency of commercial herbal products. Patients should consult a healthcare provider before taking any herbal or alternative medicine. In patients who have used feverfew extensively prior to receiving anticoagulation, antiplatelet, or thrombolytic therapy, the potential for an interaction should be considered. Clinical and laboratory observation for hematologic complications is recommended. Patients should be advised to promptly report any signs of bleeding to their physician, including pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, increased menstrual flow, vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bleeding or bruising, red or brown urine, or red or black stools.

References

Heptinstall S, White A, Williamson L, Mitchell JR "Extracts of feverfew inhibit granule secretion in blood platelets and polymorphonuclear leucocytes." Lancet 1 (1985): 1071-2
Groenewegen WA, Heptinstall S "A comparison of the effects of an extract of feverfew and parthenolide, a component of feverfew, on human platelet activity in-vitro." J Pharm Pharmacol 42 (1990): 553-7
Heck AM, DeWitt BA, Lukes AL "Potential interactions between alternative therapies and warfarin." Am J Health Syst Pharm 57 (2000): 1221-7; quiz 1228-30
Biggs MJ, Johnson ES, Persaud NP, Ratclife DM "Platelet aggregation in patients using feverfew for migraine." Lancet 2 (1982): 776
Heptinstall S, Groenewegen WA, Spangenberg P, Loesche W "Extracts of feverfew may inhibit platelet behavior via neutralization of sulphydryl groups." J Pharm Pharmacol 39 (1987): 459-65
Miller LG "Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions." Arch Intern Med 158 (1998): 2200-11

Aspirin

Generic Name: aspirin

Brand name: Arthritis Pain, Aspir 81, Aspir-Low, Bayer Childrens Aspirin, Durlaza, Ecotrin, Ecpirin, Fasprin, Halfprin, Miniprin, Aspiritab, Bayer, Bayer Low Strength, Bayer Children's, St. Joseph 81 mg Adult

Synonyms: n.a.

What is Aspirin?

Feverfew

Generic Name: feverfew

Brand name:

Synonyms: n.a.

What is Feverfew?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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