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Aspirin and Ginseng

Determining the interaction of Aspirin and Ginseng and the possibility of their joint administration.

Check result:
Aspirin <> Ginseng
Relevance: 09.04.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Talk to your doctor before using ginseng together with aspirin. Ginseng products may cause bleeding in rare cases, and taking it with other medications that can also cause bleeding such as aspirin may increase that risk. You should seek immediate medical attention if you experience any unusual bleeding or bruising, or have other signs and symptoms of bleeding such as dizziness; lightheadedness; red or black, tarry stools; coughing up or vomiting fresh or dried blood that looks like coffee grounds; severe headache; and weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Ginseng may potentiate the effects of anticoagulants, platelet inhibitors and thrombolytic agents, possibly increasing the risk of bleeding. In vitro studies have shown that one or more of the active constituents of ginseng, known as ginsenosides, can decrease platelet aggregation, although it is not known whether these constituents are absorbed or are bioactive in humans. Bleeding complications secondary to antiplatelet activity have not been reported. On the contrary, ginseng use has been associated with a reduction in INR in a patient who had been stabilized on warfarin for nine months. The mechanism for this apparent antagonism of warfarin has not been established, although ginseng has been reported to lower the plasma concentrations of warfarin.

MANAGEMENT: Patients should consult a healthcare provider before taking any herbal or alternative medicine. In general, consumption of ginseng supplements and large amounts of ginseng should preferably be avoided during use of coagulation-modifying agents. In patients who have used this herb extensively prior to receiving anticoagulation, antiplatelet or thrombolytic therapy, the potential for an interaction should be considered. Close clinical and laboratory observation for hematologic complications is recommended. Patients should be advised to promptly report any signs of bleeding to their physician, including pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, increased menstrual flow, vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bleeding or bruising, red or brown urine, or red or black stools.

References
  • Heck AM, DeWitt BA, Lukes AL "Potential interactions between alternative therapies and warfarin." Am J Health Syst Pharm 57 (2000): 1221-7; quiz 1228-30
  • Fugh-Berman A "Herb-drug interactions." Lancet 355 (2000): 134-8
  • Ang-Lee MK, Moss J, Yuan CS "Herbal medicines and perioperative care." JAMA 286 (2001): 208-16
  • Izzo AA, Ernst E "Interactions between herbal medicines and prescribed drugs: a systematic review." Drugs 61 (2001): 2163-75
  • Vaes LP, Chyka PA "Interactions of warfarin with garlic, ginger, or ginseng: nature of evidence." Ann Pharmacother 34 (2000): 1478-82
  • Yuan CS, Wei G, Dey L, et al. "Brief communication: American ginseng reduces warfarin's effect in healthy patients: a randomized, controlled Trial." Ann Intern Med 141 (2004): 23-7
  • Miller LG "Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions." Arch Intern Med 158 (1998): 2200-11
  • Janetzky K, Morreale AP "Probable interaction between warfarin and ginseng." Am J Health Syst Pharm 54 (1997): 692-3
  • Hodges PJ, Kam PC "The peri-operative implications of herbal medicines." Anaesthesia 57 (2002): 889-99
Aspirin

Generic Name: aspirin

Brand name: Arthritis Pain, Aspir 81, Aspir-Low, Bayer Childrens Aspirin, Durlaza, Ecotrin, Ecpirin, Fasprin, Halfprin, Miniprin, Aspiritab, Bayer, Bayer Low Strength, Bayer Children's, St. Joseph 81 mg Adult

Synonyms: n.a.

Ginseng

Generic Name: ginseng

Brand name:

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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