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Aspirin and Imipramine Hydrochloride

Determining the interaction of Aspirin and Imipramine Hydrochloride and the possibility of their joint administration.

Check result:

Aspirin <> Imipramine Hydrochloride

Relevance: 09.04.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using aspirin together with imipramine can increase the blood levels or add to the side effects of imipramine. This can cause dry mouth, blurred vision, fever, dizziness, confusion, stomach pain, slow heart rate, or problems with urination. If you take both medications together, tell your doctor if you have any of these symptoms. You may need a dose adjustment if you take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Preliminary evidence suggests that aspirin may increase the plasma free concentration and pharmacologic effects of imipramine by displacing it from plasma protein binding sites. In 20 patients with endogenous depression given imipramine 150 mg/day for 5 days, administration of aspirin (500 mg every 12 hours for 2 days) decreased the plasma protein binding of imipramine from 84% to 72%. Additionally, the incidence of mild and severe adverse effects associated with imipramine increased nearly 60% and 150%, respectively. Other salicylates are expected to have similar effects due to their high affinity for plasma proteins.

MANAGEMENT: Pharmacologic response to imipramine should be monitored more closely whenever a salicylate is added to or withdrawn from therapy, and the imipramine dosage adjusted as necessary. Patients should be advised to notify their physician if they experience increased adverse effects of imipramine such as dry mouth, constipation, urinary retention, blurred vision, palpitations, and tachycardia.

References

Juarez-Olguin H, Jung-Cook H, Flores-Perez J, Asseff IL "Clinical Evidence of an Interaction Between Imipramine and Acetylsalicylic Acid on Protein Binding in Depressed Patients." Clin Neuropharmacol 25 (2002): 32-36

Aspirin

Generic Name: aspirin

Brand name: Arthritis Pain, Aspir 81, Aspir-Low, Bayer Childrens Aspirin, Durlaza, Ecotrin, Ecpirin, Fasprin, Halfprin, Miniprin, Aspiritab, Bayer, Bayer Low Strength, Bayer Children's, St. Joseph 81 mg Adult

Synonyms: n.a.

What is Aspirin?

Imipramine Hydrochloride

Generic Name: imipramine

Brand name: Tofranil, Tofranil-PM

Synonyms: Imipramine

What is Imipramine Hydrochloride?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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