Aspirin and Sulfinpyrazone

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Ask your doctor before using aspirin together with sulfinpyrazone. Using these medications together may cause sulfinpyrazone be less effective. If your doctor prescribes these medications together, you may need a dose adjustment or special tests to safey use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Salicylates may antagonize the uricosuric effect of sulfinpyrazone. The exact mechanism of interaction is unknown, although therapeutic doses of aspirin have been shown to increase plasma clearance of sulfinpyrazone. In one study, acute pretreatment with aspirin (325 mg four times a day for 24 hours) resulted in increased plasma clearance of a single 400 mg dose of sulfinpyrazone in 5 of 6 subjects by 12% to 27% relative to administration of sulfinpyrazone alone. When sulfinpyrazone 200 mg and aspirin 325 mg were coadministered four times a day for one week, plasma clearance of sulfinpyrazone increased up to 229%. The investigators theorized that aspirin may displace sulfinpyrazone from plasma protein binding sites, resulting in a redistribution of sulfinpyrazone into peripheral compartments and increased amount of free drug for hepatic metabolism. In vitro data also suggest that sulfinpyrazone may interfere with the irreversible effects of aspirin (especially low doses) on platelets, although the clinical significance is unknown.

MANAGEMENT: Salicylates should not be used during sulfinpyrazone therapy for gouty arthritis. However, occasional small doses of salicylates are not expected to interact significantly.

Aspirin

Generic Name: aspirin

Brand name: Arthritis Pain, Aspir 81, Aspir-Low, Bayer Childrens Aspirin, Durlaza, Ecotrin, Ecpirin, Fasprin, Halfprin, Miniprin, Aspiritab, Bayer, Bayer Low Strength, Bayer Children's, St. Joseph 81 mg Adult

Synonyms: n.a.

What is Aspirin?

Sulfinpyrazone

Generic Name: sulfinpyrazone

Brand name:

Synonyms: Sulfinpyrazone (Oral)

What is Sulfinpyrazone?