Aspirin and Ticlopidine

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using aspirin together with ticlopidine may increase the risk of bleeding, especially gastrointestinal bleeding. Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for potential complications. You should seek immediate medical attention if you experience any unusual bleeding or bruising, or have other signs and symptoms of bleeding such as dizziness; lightheadedness; red or black, tarry stools; coughing up or vomiting fresh or dried blood that looks like coffee grounds; severe headache; and weakness. Do not take any other medications containing aspirin or other pain relievers such as ibuprofen or naproxen without your doctor's knowledge or consent. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Ticlopidine may potentiate the effect of aspirin on collagen-induced platelet aggregation. Other salicylates that also inhibit platelet aggregation may be similarly impacted. An increased risk of bleeding should be anticipated, especially in patients with a history of gastrointestinal (GI) ulceration or bleeding. Conversely, aspirin does not alter the ticlopidine-mediated inhibition of adenosine diphosphate-induced platelet aggregation.

MANAGEMENT: The safety of concomitant use of ticlopidine with aspirin or other platelet-inhibiting salicylates has not been established. Ticlopidine labeling recommends against long-term coadministration with aspirin. However, ticlopidine (250 mg twice daily) may be given with antiplatelet dosages of aspirin for up to 30 days following successful coronary artery stent implantation to reduce the risk of blood clots forming inside the stent. Close monitoring for bleeding complications, particularly GI bleeding, is advised during treatment.

Aspirin

Generic Name: aspirin

Brand name: Arthritis Pain, Aspir 81, Aspir-Low, Bayer Childrens Aspirin, Durlaza, Ecotrin, Ecpirin, Fasprin, Halfprin, Miniprin, Aspiritab, Bayer, Bayer Low Strength, Bayer Children's, St. Joseph 81 mg Adult

Synonyms: n.a.

What is Aspirin?

Ticlopidine

Generic Name: ticlopidine

Brand name: Ticlid

Synonyms: n.a.

What is Ticlopidine?