Aspirin and Omeprazole Tablets and Nelfinavir Tablets

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Ask your doctor before using omeprazole together with nelfinavir. Omeprazole may decrease the effects of nelfinavir. Ask your doctor to consider an alternative to omeprazole. If your doctor prescribes these medications together, you may need a dose adjustment to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Concurrent use of proton pump inhibitors may decrease the oral bioavailability of nelfinavir and reduce its concentrations in plasma. Nelfinavir solubility may decrease with increasing pH, thus inhibition of gastric acid secretion may interfere with dissolution of the drug. In one study, administration of omeprazole (40 mg once daily) 30 minutes before nelfinavir (1250 mg twice a day) for 4 days reduced the peak plasma concentration, trough plasma concentration, and systemic exposure (AUC) of nelfinavir by a little over one-third.

MANAGEMENT: Given the risk of reduced viral susceptibility and resistance development associated with subtherapeutic antiretroviral drug levels, use of proton pump inhibitors is not recommended in patients treated with nelfinavir.

Aspirin and Omeprazole Tablets

Generic Name: aspirin / omeprazole

Brand name: Yosprala

Synonyms: Aspirin and omeprazole, Aspirin and Omeprazole

What is Aspirin and Omeprazole Tablets?

Nelfinavir Tablets

Generic Name: nelfinavir

Brand name: Viracept

Synonyms: Nelfinavir

What is Nelfinavir Tablets?